基本信息

宋纯理 医学博士 北京大学第三医院 副院长 骨科教授 博士生导师 博士后合作导师

北医三院医学创新研究院副院长 骨质疏松和骨代谢中心主任

教育经历

2002年毕业于北京大学并获医学博士学位。

工作经历（同教育经历，分行列出）

 2006-2009 北医三院科研处副处长

 2009-2012 北医三院院长助理

 2010-2018北医三院骨科副主任、研究员、教授。

 2018-至今 北医三院 副院长

研究方向（本人业务专长）

骨质疏松及代谢性骨病、肌肉骨骼退行性疾病

主要学术兼职

北京医学会骨质疏松与骨矿盐疾病分会 副主任委员

中华医学会骨质疏松与骨矿盐疾病分会 常委委员

中华预防医学会体育运动与健康分会 副主任委员

中国老年医学学会骨科分会副主任委员

北京慢性病防治与健康教育研究会骨质疏松专业委员会 主任委员

《中华医学会骨质疏松与骨矿盐疾病》编委

《Journal of Orthopaedic Translation》编委

《中华医学科研管理杂志》编委

北京市科技进步二等奖 2024年

全国创新争先奖 2020年

全国卫生系统“创先争优”先进个人2011年

教育部新世纪优秀人才 2010年

北京大学医学部优秀青年学者 2009年

主持国家“863”课题，国家重点研发计划，国家自然科学基金重点项目、国家自然科学基金面上项目，北京市自然科学基金等。主持RCT研究13项，参与5项。以责任作者在国内外期刊发表100余篇论文；获批5项国内专利，2项国外专利，主编主译专著7部；荣获国家奖1项。

近年来主要论文（通讯作者） 

1.         Kang Song, Xuezheng Geng, Huan Yin, Yanzhu Shi, Jiawei Wang, Jiayu Yu, Mateng Bai, Lizhen Wang, Yurui Xue, Chunli Song, Yubo Fan. Schottky engineering of GDYO@Pt to boost piezoelectric and oxidative stress modulation for accelerated cranial regeneration. Nat Commun. 2025 Sep 26;16(1):8523. doi: 10.1038/s41467-025-63550-8.

2.         Liu X, Liu H, Yang G, Jiang Z, Cui S, Zhang Z, Wang H, Tao L, Sun Y, Song Z, Hong T, Yang J, Gao T, Zhang J, Li X, Zhang J, Sang Y, Yang Z, Xue K, Wu S, Zhang P, Yang J*, Song C*, Wang G*. Ageneralist medical language model for disease diagnosis assistance. Nat Med. 2025 Jan 8. DOI: 10.1038/s41591-024-03416-6

3.         Zheng XQ, Wang DB, Jiang YR, Song CL*. Gut microbiota and microbial metabolites for osteoporosis. Gut Microbes. 2025;17(1):2437247. DOI: 10.1080/19490976.2024.2437247

4.         Xuan-Qi Zheng, Zhi-Yuan Guan, Yun-Di Zhang, Chun-Li Song. Different role of the gut microbiota in postmenopausal and senile osteoporosis. Bone Res. 2025 Jun 13;13(1):63. doi: 10.1038/s41413-025-00432-1.

5.         Wang, H, Tao, L, Cui, L, Chen, … Song C*. Randomized trial of influence of vitamin D on the prevention and improvement of symptomatic COVID-19. Sci Rep. 2024 Dec 31;14(1): 32158. DOI: 10.1038/s41598-024-66267-8

6.         Wang H, Huang J, Tao L, Liu D, Song C*. Efficacy and safety of minodronate in the treatment of postmenopausal osteoporosis with low back pain: a single-center, randomized and open-label controlled trial. Trials. 2024;25(1):534. DOI: 10.1186/s13063-024-08364-7

7.         Huang J, Wu T, Jiang YR, Zheng XQ, Wang H, Liu H, Wang H, Leng HJ, Fan DW, Yuan WQ, Song CL*. β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture. Bone Res. 2024 Mar 21;12(1):18.  DOI: 10.1038/s41413-024-00321-z

8.         Feng J, Huang J, Li B, Zheng X, Wang J, Wang S, Zhan S, Song C*. Association between weather and hip fracture in adults: a nationwide study in China 198 cities. Arch Osteoporos. 2023;18(1):70. DOI: 10.1007/s11657-023-01248-4

9.         Guan Z, Xuanqi Z, Zhu J, Yuan W, Jia J, Zhang C, Sun T, Leng H, Jiang C, Xu Y, Song C*. Estrogen deficiency induces bone loss through the gut microbiota. Pharmacol Res. 2023 Oct;196:106930. DOI: 10.1016/j.phrs.2023.106930

10.     Zheng XQ, Lin JL, Huang J, Wu T, Song CL*. Targeting aging with the healthy skeletal system: The endocrine role of bone. Rev Endocr Metab Disord. 2023 Aug;24(4):695-711. DOI: 10.1007/s11154-023-09812-6

11.     王欢(学)宋纯理 双膦酸盐的药学特点与临床应用 中华骨质疏松和骨矿盐疾病杂志 2023 163 281-289

12.     王欢(学)，宋纯理 双膦酸盐的药学特点与临床应用 中华骨质疏松和骨矿盐疾病杂志 2023 1603 281-289

13.     Zheng XQ, Xu L, Huang J, Zhang CG, Yuan WQ, Sun CG, Zhang ZS, Wei C, Wang JX, Cummings SR, Xia WB, Wang SF, Zhan SY, Song CL*. Incidence and cost of vertebral fracture in urban China: a 5-year population-based cohort study. Int J Surg. 2023 Jul 1;109(7):1910-1918. DOI:10.1097/JS9.0000000000000411 (Q1, IF:12.5)

14.     Zheng XQ, Huang J, Lin JL, Song CL*. Pathophysiological mechanism of acute bone loss after fracture. J Adv Res. 2023 Jul;49:63-80. DOI: 10.1016/j.jare.2022.08.019

15.     Guan Z, Yuan W, Jia J, Zhang C, Zhu J, Huang J, Zhang W, Fan D, Leng H, Li Z, Xu Y, Song C*. Bone mass  loss  in  chronic  heart  failure  is  associated  with  sympathetic  nerve  activation.  Bone.  2023 Jan; 166:116596. DOI: 10.1016/j.bone.2022.116596

16.     Yuan W, Ren X, Zhu J, Huang J, Zhang W, Zhang C, Guan Z, Wang H, Leng H, Song C*. Single-intraosseous simvastatin injection suppresses cancers via activating CD8+ T cells. Biomed Pharmacother. 2022; 155:113665. DOI: 10.1016/j.biopha.2022.113665

17.     Sun T, Huang J, Zhang W, Zheng X, Wang H, Liu J, Leng H, Yuan W, Song C*. Simvastatin-hydroxyapatite coatings prevent biofilm formation and improve bone formation in implant-associated infections. Bioact Mater. 2022 Aug 13;21:44-56. DOI: 10.1016/ j. bioactmat.2022.07.028

18.     Zhang C, Zhu J, Jia J, Guan Z, Sun T, Zhang W, Yuan W, Wang H, Song C*. Long-term pretreatment with alendronate inhibits calvarial defect healing in an osteoporotic rat model. J Bone Miner Metab. 2021 Nov;39(6):925-933. DOI: 10.1007/s00774-021-01235-0

19.     Zhang C, Zhu J, Jia J, Guan Z, SunT, Zhang W, Yuan W, Wang H, Leng H, Song C*. Effect of Single Versus Multiple Fractures on Systemic Bone Loss in Mice. J Bone Miner Res. 2021 Mar;36(3):567-578. DOI: 10.1002/jbmr.4211

20.     Pan Z, Chu H, Zhang Y, Hong X, Liang L, Zhao W, Chen Y, Song C*. Perspectives of research ethics committee members on human challenge studies in the development of vaccines against COVID-19: a mixed methods study. Ann Palliat Med. 2021 Jun;10(6):6259-6269. DOI: 10.21037/apm-20-2622

21.     Dang L, Zhu J, Song C*. The effect of topical administration of simvastatin on entochondrostosis and intramembranous ossification: An animal experiment. J Orthop Translat. 2021 Jan 27; 28:1-9. DOI: 10.1016/j.jot.2020.11.009

22.     Zhang C, Zhu J, Jia J, Guan Z, Sun T, Zhang W, Yuan W, Wang H, Leng H, Song C*. Effect of Single Versus Multiple Fractures on Systemic Bone Loss in Mice. J Bone Miner Res. 2021 Mar;36(3):567-578.   DOI: 10.1002/jbmr.4211

23.     Zhang C, Zhu J, Jia J, Guan Z, Sun T, Zhang W, Yuan W, Wang H, Leng H, Song C*. Once-weekly parathyroid hormone combined with ongoing long-term alendronate treatment promotes osteoporotic fracture healing in ovariectomized rats. J Orthop Res. 2021 Oct;39(10):2103-2115. DOI: 10.1002/jor.24953

24.     Zhang C, Song C*. Combination Therapy of PTH and Antiresorptive Drugs on Osteoporosis: A Review of Treatment Alternatives. Front Pharmacol. 2021 Jan 27; 11: 607017. DOI: 10.3389/ fphar.2020.607017

25.     Liu Q, Bi G, Chen G, Guo X, Tu S, Tong X, Xu M, Liu M, Wang B, Jiang H, Wang J, Li H, Wang K, Liu D, Song C*. Time-Dependent Distribution of Hydroxychloroquine in Cynomolgus Macaques Using Population Pharmacokinetic Modeling Method. Front Pharmacol. 2021 Jan 14; 11:602880. DOI: 10.3389/fphar.2020.602880

26.     韩耕愚(学)宋纯理,李润庭(学)(并列第一) 静脉注射唑来膦酸所致急性期反应及他汀的预防作用 中华骨质疏松和骨矿盐疾病杂志 2020 13 61-67

27.     Zhu J, Zhang C, Jia J, Yuan W, Zhang M, Leng H, Song C*. Effect of weekly teriparatide injections on osteoporotic fracture healing: protocol for a double-blind, randomised controlled trial. BMJ Open. 2021 Apr 1;11(4):e043137. DOI: 10.1136/bmjopen-2020-043137

28.     Zhu J, Zhang C, Jia J, Wang H, Leng H, Xu Y, Wu C, Zhang Q, Song C*. Osteogenic effects in a rat osteoporosis model and femur defect model by simvastatin microcrystals. Ann N Y Acad Sci. 2021 Mar;1487(1):31-42. DOI: 10.1111/nyas.14513

29.     Zhang W , Sun C , Zhu J , Zhang W , Leng H , Song C*. 3D printed porous titanium cages filled with simvastatin hydrogel promotes bone ingrowth and spinal fusion in rhesus macaques. Biomater Sci. 2020 Aug 7;8(15):4147-4156. DOI: 10.1039/d0bm00361a

30.     Yuan W, Song C*. The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways. Biochem Res Int. 2020 Feb 11; 2020:4186308. DOI: 10.1155/2020/ 4186308

31.     Zhang C, Feng J, Wang S, Gao P, Xu L, Zhu J, Jia J, Liu L, Liu G, Wang J, Zhan S, Song C*. Incidence of and trends in hip fracture among adults in urban China: A nationwide retrospective cohort study. PLoS Med.2020 Aug 6;17(8):e1003180. DOI: 10.1371/journal.pmed.1003180

32.     Yuan W, Hai B, Ren X, Zhu J, Zhang C, Guan Z, Jia J, Wang H, Cao B, Song C*. Single-dose local intraosseous injection of simvastatin suppresses breast cancer with tumor vascular normalization. Transl Oncol. 2020 Dec;13(12):100867. DOI: 10.1016/j.tranon.2020.100867

33.     Guan Z, Guan X, Gu K, Lin X, Lin J, Zhou W, Xu M, Wan F, Zhang Z, Song C*. Short-term outcomes of on- vs off-pump coronary artery bypass grafting in patients with left ventricular dysfunction: a systematic review and meta-analysis. J Cardiothorac Surg. 2020 May 11;15(1):84. DOI: 10.1186/s13019-020-01115-0

34.     Zhu J, Liu C, Jia J, Zhang C, Yuan W, Leng H, Xu Y, Song C*. Short-term caloric restriction induced bone loss in both axial and appendicular bones by increasing adiponectin. Ann N Y Acad Sci. 2020 Aug;1474(1):47-60. DOI: 10.1111/nyas.14380

35.     Guan X, Guan Z, Song C*. Expression profile analysis identifies key genes as prognostic markers for metastasis of osteosarcoma. Cancer Cell Int. 2020 Mar 30; 20: 104. DOI: 10.1186/s12935-020-01179-x

36.     Liu C, Zhu J, Hai B, Zhang W, Wang H, Leng H, Xu Y, Song C*. Single Intraosseous Injection of Simvastatin Promotes Endothelial Progenitor Cell Mobilization, Neovascularization, and Wound Healing in Diabetic Rats. Plast Reconstr Surg. 2020 Feb;145(2):433-443.  DOI: 10.1097/PRS.0000000000006502

37.     Yuan W, Hai B, Ren X, Zhu J, Zhang C, Guan Z, Jia J, Wang H, Cao B, Song C*. Single-dose local intraosseous injection of simvastatin suppresses breast cancer with tumor vascular normalization. Transl Oncol. 2020 Dec;13(12):100867. doi: 10.1016/j.tranon.2020.100867. Epub 2020 Sep 18. DOI: 10.1016/j.tranon.2020.100867

38.     Guan Z, Jia J, Zhang C, Sun T, Zhang W, Yuan W, Leng H, Song C*. Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice. Clin Sci (Lond). 2020 Dec 11;134(23):3159-3174. DOI: 10.1042/CS20201224 (Q1, IF:6.7)

39.     Zhang C, Zhu J, Jia J, Guan Z, Sun T, Zhang W, Yuan W, Wang H, Leng H, Song C*. Effect of Single Versus Multiple Fractures on Systemic Bone Loss in Mice. J Bone Miner Res. 2021 Mar;36(3):567-578. DOI: 10.1002/jbmr.4211

40.     Dang L, Zhu J, Liu Z, Liu X, Jiang L, Wei F, Song C*. A new approach to the treatment of spinal instability: Fusion or structural reinforcement without surgery? Med Hypotheses. 2020 Nov;144:109900. DOI: 10.1016/j.mehy.2020.109900

41.     张丞贵(学)，宋纯理 局部骨骼与系统器官的内分泌对话 中华骨质疏松和骨矿盐疾病杂志 2019 12 5511-516

42.     祝俊雄(学),宋纯理 骨质疏松及其骨折的局部药物治疗 中国骨质疏松杂志  2018 246 806-813

43.     Guo Q, Liu C, Hai B, Ma T, Zhang W, Tan J, Fu X, Wang H, Xu Y, Song C*. Chitosan conduits filled with simvastatin/Pluronic F-127 hydrogel promote peripheral nerve regeneration in rats. J Biomed Mater Res B Appl Biomater. 2018 Feb;106(2):787-799. DOI: 10.1002/jbm.b.33890

44.     Zhang W, Zhu J, Ma T, Liu C, Hai B, Du G, Wang H, Li N, Leng H, Xu Y, Song C*. Comparison of the effects of once-weekly and once-daily rhPTH (1-34) injections on promoting fracture healing in rodents. J Orthop Res. 2018 Apr;36(4):1145-1152. DOI: 10.1002/jor.23750 en

1.   《现代骨科基础与临床》参编，人民卫生出版社；

2.   《骨质疏松椎体压缩性骨折》参编，人民卫生出版社；

3.   《创伤骨科学》参编，天津科技翻译出版公司；

4.   《衰老相关疾病及综合征》参编，人民卫生出版社；

5.   《骨骼研究常用技术》主译，北京大学医学出版社；

6.   《骨肌运动功能学》副主译，北京大学医学出版社；

7.   《骨质疏松症健康实践指南》，主译，山东科学技术出版社；

8.   《骨质疏松性骨折的内外科处理》主译，山东科学技术出版社。